Speaker: Prof.ssa Donata Luiselli
Title: Molecular Anthropology and Evolutionary Medicine: Insights from the Italian Case
Abstract:
In recent years, the application of genomics to human populations has enabled researchers to reconstruct, in remarkable detail, the complex evolutionary history of Italy, a pivotal region at the crossroads of migrations between Africa, Europe, and Asia. Studies have revealed a marked genetic structure along the Italian peninsula and its islands, shaped by successive historical layers, beginning with Upper Palaeolithic colonization, the spread of Neolithic agriculture, migrations from the Eurasian steppe, and later contributions from the Middle East and North Africa. Genomic analyses, now increasingly supplemented by data from ancient DNA have illuminated the demographic dynamics that have shaped the genetic diversity of the Italian
population. These studies have also identified signals of natural selection in genes involved in lipid metabolism, immune response, and adaptation to diverse dietary practices and climatic conditions. Notably, populations in Northern Italy exhibit genetic adaptations favoring lipid metabolism in colder climates, while Southern Italy and Sicily show variants linked to heightened immune responses, possibly reflecting historically higher infectious disease burdens. This evidence supports the framework of evolutionary medicine, suggesting that the genetic makeup of modern populations, shaped by past environmental pressures, can help explain
present-day susceptibilities to cardiovascular, metabolic, and autoimmune diseases. Our current health, in many respects, reflects the legacy of our evolutionary past.
